发布时间:2022-08-17 14:43:00

  标签:形态发生紊乱关联激活因子 抗体 华远化学

  形态发生紊乱关联激活因子1抗体应用技术

 

  中文名称 形态发生紊乱关联激活因子1抗体

  英文名称 DAAM1

  别 名 DAAM 1; DAAM-1; Dishevelled associated activator of morphogenesis 1; FLJ41657; KIAA0666; DAAM1_HUMAN.

  研究领域 细胞生物 免疫学

  抗体来源 Rabbit

  克隆类型 Polyclonal

  交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

  产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 形态发生紊乱关联激活因子1抗体(石蜡切片需做抗原修复)

  not yet tested in other applications.

  optimal dilutions/concentrations should be determined by the end user.

  分 子 量 123kDa

  细胞定位 细胞浆

  性 状 Lyophilized or Liquid

  浓 度 1mg/1ml

  免 疫 原 KLH conjugated synthetic peptide derived from human DAAM1

  亚 型 IgG

  纯化方法 affinity purified by Protein A

  储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

  保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

  形态发生紊乱关联激活因子1抗体产品介绍 background:

  DAAM1 (Dishevelled associated activator of morphogenesis 1) is a diaphanous-related formin which binds to dishevelled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex assembly. It is an essential component of noncanonical Wnt signaling. DAAM1 also communicates with Rho GTPases, CIP4 and Src in the regulation of the signalling pathways that co-ordinate the dynamics of the actin filament system. DAAM1 may be a coordinator of endocytosis and cytoskeletal remodeling.

  Function:

  Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.

  Subunit:

  Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA.

  Subcellular Location:

  Cytoplasm. Note=Perinuclear.

  Tissue Specificity:

  Expressed in all tissues examined.

  Database links:

  Belongs to the formin homology family.

  Contains 1 DAD (diaphanous autoregulatory) domain.

  Contains 1 FH1 (formin homology 1) domain.

  Contains 1 FH2 (formin homology 2) domain.

  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.

  形态发生紊乱关联激活因子1抗体应用技术 华远化学公司主要业务为向大专院校、科研机构,药企、化工企业提供高品质、特殊规格的化学产品和技术解决方案,已经形成了累计服务超过1000家客户,提供高规格产品超过6000种,合作行业和产业伙伴超过1200家的体量和规模,积累了丰富的经验和良好的口碑。基于长期的行业经验和积累,我司已经形成了既能满足研发类客户对产品种类、包装、纯度的特殊要求,也能适应企业从小试、中试到规模化等各个阶段的综合需求的核心能力。

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